Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Glutamatergic Synapse Formation in Developing Zebrafish Embryos

Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons

"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of Western Mosquitofish, Gambusia affinis (Mosquitofish). To study gap junctions' ...

Gap junctions and connexins: potential contributors to the immunological synapse.

Gap junctional communication is a widespread mechanism for metabolic coupling of adjoining cells. In the immune system, evidence has built up showing that lymphocytes possess the protein building blocks of gap junctions, the connexins. The most widespread is connexin 43, but connexin 40 is also present in secondary lymphoid organs. Inhibitors of gap junctional communication, especially the high...

Synaptic integration and dendritic excitability in cerebellar Purkinje neurons

Dendrites receive most of the synaptic input to the neuron, but their contribution to synaptic integration is not well understood. In this thesis I investigate synaptic integration in Purkinje neurons in cerebellar slices, focusing on the contribution of dendritic excitability using simultaneous somatic and dendritic patch-clamp recordings. I first investigated the ionic conductances underlying...

Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons

Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups a...